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Apply gentle pressure with a clean cotton pad if needed, but avoid rubbing the site vigorously, which can increase irritation and bruising risk

Long-term efficacy and tolerability of PCSK9 targeted therapy: a review of the literature

Clinical approach recommendations include starting with the most conservative effective therapy, optimizing tirzepatide dosing before adding other agents, regular monitoring of cardiovascular parameters and metabolic markers, and setting realistic weight loss goals (5-10% initial target)

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It undergoes hepatic metabolism to the active metabolite desipramine, which preferentially inhibits norepinephrine reuptake