Documented Long-Term Side Effects of NSAIDs Regular or long-term NSAID use has been associated with: Damage to the gut lining, increasing intestinal permeability (leaky gut) and immune activation (27,29,31) Reduced absorption of key nutrients, including iron, folate, and vitamin C (28,29) Delayed tissue repair , particularly in connective tissue where prostaglandins are required for healing (32) Kidney stress and electrolyte imbalance , especially during dehydration or endurance activity (30) Increased cardiovascular risk , particularly with higher doses or prolonged exposure (30) These effects help explain why NSAIDs may temporarily reduce pain while progressively impairing healing capacity, increasing systemic inflammation, and slowing long-term recovery
Medical and Pregnancy Considerations Pregnant or breastfeeding
How does the Melanotan-1 pathway relate to ASIP and skin health
Annual lab work monitoring IGF-1, glucose, and liver function provides good safety oversight for extended research
Mast Cell Activation Syndrome (MCAS): KPV's ability to reduce cytokine secretion from mast cells has led to interest in its use for MCAS, where dysregulated mast cell degranulation produces systemic inflammatory symptoms
