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The resultant glucose regulatory effect of magnesium and insulin could also be responsible for the recovery in body weight of these treatment groups (magnesium and insulin) compared to diabetic untreated animals that had a progressive and significant reduction in body weight considering their initial values (Table 1)

Medicina 58:340

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10.1016/j.indcrop.2017.05.048 368

Studies indicate that metformin treatment results in necrotic cell death, particularly in cancer cells treated with combined therapies, due to its ability to induce sustained energy stress and subsequent cellular damage