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Structurally it is the GLP-1 backbone with substitutions that resist enzymatic breakdown plus a fatty-acid chain that binds albumin, slowing clearance

Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis

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In humans, GLP-1Rs are found in a variety of tissues, including pancreatic islets, the lungs, the kidneys, the gastrointestinal tract, the central nervous system, the vagus nerve, endothelial cells and smooth muscle cells, as well as in atrial and ventricular cardiomyocytes

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