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Whilst 9 -THC prolonged the immobility time forced swim test (Egashira et al., 2008), other cannabinoids e.g., cannabidiol exhibited antidepressant-like effects (Zanelati et al., 2010)
Therapeutic supplementation often includes omega-3 fatty acids, curcumin, resveratrol, boswellia, and specialized enzymes that help modulate inflammatory signaling pathways without the side effects associated with pharmaceutical anti-inflammatories
For example, as we described above that MTHFR polymorphism is associated with early onset of schizophrenia and the severity of depressive symptoms in MDD
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