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In healthy individuals GLP-1 and GIP together add up to about 60% of postprandial insulin secretion

Besides lowering blood glucose and reducing weight (incredibly visceral fat), GLP-1R agonists can also lower blood pressure, improve blood lipid disorder, and reduce fatty liver (140)

All patients were required to have continuous enrollment of at least 12 months before cohort entry and meet eligibility criteria for one of the five cohort studies defined below (study design diagrams depicted in Supplementary Figs

Weight loss itself whether from diet, bariatric surgery, or GLP-1 medications is a risk factor for gallstones, not necessarily the medicine

GLP-1 RAs are associated with gastrointestinal side effects such as nausea, vomiting and diarrhea most prominent during initiation and dose titration