Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing
It is approved for chronic weight management in adults and children 6 years and older with obesity due to specific genetic conditions, including proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency, or Bardet-Biedl syndrome
Natural History/Prognosis CVS resolves, in most children (5070%) in late childhood or early adolescence (2830, 73, 74)
Many ongoing clinical trials on AD are focused on disease-modifying therapies (DMTs) that target the causes and can change the course of AD
Together, these developments indicate that apelin/APJ represents a system where the translational story is still evolving rather than resolved