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Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1 pathway on the brain of APP/PS1 transgenic mice

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To facilitate the calculations and analysis, an artificial chimera molecule was built using the X-ray fragments found in subpockets A-C in PDB:6FP4 and PDB:6FTC and connected by a short CH 2 CH 2 linker