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While approximately one-third of diagnosed individuals experience mild visual improvement within the initial six months, the vast majority are left with lasting structural blind spots or reduced acuity

For diabetes patients specifically, TRANSCEND-T2D-1 suggests meaningfully better tolerability than the general obesity population worth factoring into expectation-setting

Safetywise, larazotide has generally shown a favorable profile in trials, with adverse events not significantly different from placebo and mainly involving mild GI symptoms

the commenter requested that CMS no longer include these refinements in the table published each year

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