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However, a2020 studyindicates that the risk of a flare following oral steroid use is low

Besides the thyroid hormone pathway directly, there might be some other factors that are causing problems

Optimal levels of glutathione, cysteine, and selenium may strengthen the gut lining

However, this is less likely if the body cannot synthesize glutathione from nutrients 21 , an ability that decreases with age

Future medicinal chemistry efforts may yield next-generation compounds with enhanced properties, including improved tissue selectivity, modified pharmacokinetics, or additional mechanistic activities that complement NNMT inhibition