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Neurobiol Pain

Silber SJ, Kato K, Aoyama N, et al

Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: The COR-BMOD trial

The mechanism of action involves binding to both GIP and GLP-1 receptors, which are expressed throughout the body, including in pancreatic beta cells, the gastrointestinal tract, and the central nervous system

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