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Impairment of Fertility In chronic toxicity studies of valproate in juvenile and adult rats and dogs, administration of valproate resulted in testicular atrophy and reduced spermatogenesis at oral doses of 400 mg/kg/day or greater in rats (approximately equivalent to or greater than the maximum recommended human dose (MRHD) on a mg/m2basis) and 150 mg/kg/day or greater in dogs (approximately equal to or greater than the MRHD on a mg/m2 basis)

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Liver, spleen, and pancreas are often affected

Studies have shown that after mitochondrial irreversible and complete aging, a higher NAD+/NADH ratio helps reduce glycolysis, avoiding the abnormal metabolism of tryptophan due to lysosome-associated membrane protein 2 (LAMP-2) deficiency [16]

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