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463 Colchicine has been shown to alter the expression of proteins on the surfaces of endothelial cells, white blood cells, and platelets, which may interfere with their ability to participate in thrombosis

The woman who had purchased the supplement only learned this information after seeing her doctor due to several alarming symptoms, including a racing heart, constant nausea, and spasming fingers

They may contain unknown harmful ingredients

But attempts to maintain that weight loss can mean ongoing, possibly lifelong, injections which can prove costly, and much of the weight lost can be regained in a relatively short period of time if the medication is stopped

The STEP 1 trial (Wilding et al., New England Journal of Medicine, 2021) reported 14.9% mean weight loss with FDA-approved 2.4mg semaglutide over 68 weeks