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The pancreas is a gland that releases insulin and other enzymes needed to digest food

Rectangular boxes represent the substrates that can vary in the model, and the ellipses contain the acronyms of the enzymes that catalyze particular reactions

Thus, it is inferred that lithium increases mitochondrial respiration, decreases the pro-apoptotic enzyme glycogen synthase kinase-3, and inhibits the expression of the pro-apoptotic genes Bax and p53

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Decreased expression of synapse-related genes and loss of synapses in major depressive disorder