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It works by: Slowing gastric emptying , which prolongs feelings of fullness after eating Reducing appetite through effects on brain regions that regulate hunger Improving glycaemic control by enhancing insulin secretion when blood glucose is elevated Reducing glucagon secretion , which helps prevent excessive glucose production by the liver The medication is administered as a once-weekly subcutaneous injection, with doses gradually increased over 16-20 weeks to the maintenance dose of 2.4 mg weekly (though some patients may remain on 1.7 mg if the higher dose is not tolerated)
Subgroup analysis revealed that subcutaneous injection of semaglutide is more likely to cause adverse events related to the endocrine system compared to oral administration
With the GLP-1 receptor there is the pathway linked to insulin control, but also a pathway that recruits the signalling molecule beta arrestin, which causes the side effects but also results in the whole receptor and drug molecule being taken inside the cell, shutting down any further activity
BMJ open gastroenterology, 12(1), e001704
Thats why your progress may look different from someone elses, even on the same medication
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