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The compound does not appear to have carcinogenic activity in the models tested, and its interaction with tumor biology, a legitimate concern given that angiogenesis also supports tumor vascularization, has been examined in several studies without evidence of tumor promotion at physiological doses

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More notably, some genes were involved in metabolic pathways, including the glutathione-related gene GSTM3 , the lactate dehydrogenase LDHC and the lipid metabolism-related genes APOA4 , FAR2 and ACSM1 , among others (Fig

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