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Safety Monitoring Recommendations Based on the available clinical trial data, clinicians prescribing orforglipron should: (1) counsel patients about expected GI side effects during dose escalation, (2) follow the recommended dose-titration schedule to minimize GI intolerance, (3) monitor for signs of pancreatitis and discontinue if suspected, (4) assess hepatic and renal function at baseline and periodically, (5) screen for personal or family history of MTC or MEN 2, and (6) review concomitant medications for potential CYP3A-mediated drug interactions

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It should also be noted that 8 days of water-only fasting also resulted in a decrease in the volume of excreted urine and an increase in its specific gravity

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Poor glycemic control, persistent albuminuria, and continuous decline in eGFR should lead to the addition of a GLP1-RAs with proven renal benefit