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This metabolic reprogramming leads to the continuous production and accumulation of large amounts of lactate, which in turn causes acidification of the TME, promoting cancer cell growth, migration, and angiogenesis (42, 43)

Treg, regulatory T cell.ecaption Fig

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36 This phenomenon was first observed in mast cells and results from Fc epsilon receptor I (FcRI) stimulation, causing a transient, transcription-independent increase in intracellular zinc