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14-15 It is important to note that obesity is a chronic disease, and discontinuing semaglutide can lead to weight regain due to a decrease in lean mass and basal metabolic rate (BMR)

The increased inflammatory environment may cause insulin resistance and reduced glucose uptake in insulin-sensitive tissues (muscle and liver), thereby causing glucose intolerance

Biochem J 368: 761768

When recovery capacity falls behind load, injuries accumulate

The SUSTAIN-6 trial demonstrated that Ozempic significantly reduces the risk of major adverse cardiovascular events (MACE) in patients with type 2 diabetes and established cardiovascular disease