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[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Gemede H.F., Ratta N., Haki G.D., Woldegiorgis A.Z., Beyene F

The mechanism of action involves several pathways: Appetite suppression : Semaglutide acts on receptors in the brain (particularly in the hypothalamus) to reduce hunger and increase feelings of satiety

The science backs this up: patients with fatty liver disease saw their inflammation markers drop significantly, and the effects lasted months after treatment

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Of note, KD of CAPN2 abrogated the inhibitory effect of aloxistatin on fibroblast activation markers CTGF and ACTA2 under TGF1 stimulation