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Patients with type 2 diabetes mellitus (T2DM) have an increased risk of developing chronic kidney disease (CKD)

The TRIUMPH-4 Phase 3 results announced in December 2025 showed 28.7% average weight loss the highest ever recorded in a Phase 3 obesity trial, exceeding both tirzepatide's results and bariatric surgery benchmarks

HUBERMAN: There's some nice studies showing telomere expansion

Could it cause subtle organ damage over time

Sometimes the answer is not push through it. The answer may be to slow the titration, adjust the dose, treat constipation, improve hydration, change eating patterns, or pause and reassess