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Gly-b-MCA is a potent anti-cholestasis agent with potential clinical application in treating human cholestasis

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319 As a competitive endogenous RNA (ceRNA), the lncRNA SNHG5 regulates intestinal epithelial cell proliferation and apoptosis through the miR-375/JAK2 axis, and the knockdown of the lncRNA SNHG5 significantly improves the dysfunction of intestinal epithelial cells

Disclosures: ATSUSHI UMEDA: EA Pharma Co., Ltd.: Employee, YASUKO OWADA: Nothing to Disclose, KENICHI FURIHATA: Kissei Pharmaceutical Company: Advisor, SHUICHI TSURUOKA: Nothing to Disclose, Atsushi Nakajima: Nothing to Disclose, RYOSUKE MIKAMI: Nothing to Disclose, MASAKAZE OAKU: Nothing to Disclose, TAKUYA YAMAMOTO: Nothing to Disclose, TETSUO YANO: Nothing to Disclose, YUJI KUMAGAI: Nothing to Disclose 593 DNA METHYLOME ANALYSIS REVEALS EPIGENETIC ALTERATION OF COMPLEMENT GENES IN ADVANCED MASLD Won Kim 1 Young Ho So 1 YONG JIN JUNG 1 Sae Kyung Joo 1 , 1 Boramae Medical Center Background: Blocking the complement system presents a promising strategy to impede the progression of metabolic dysfunction-associated steatotic liver disease (MASLD)