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In bacteria, the evolution of protein paralogs that perform identical functions in cells, but with distinct inorganic cofactor requirements or none at all, is a particularly dramatic and sometimes overlooked example of metabolic and evolutionary adaptation to bioavailable metals

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POTENTIAL ROLE OF MELATONIN ANALOGS AS THERAPEUTICS IN CANCER THERAPY One of the biggest obstacles to the use of melatonin as a clinically effective anticancer is its short half-life (between 20 and 40 min)

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