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The remaining missing data were subjected to kNN imputation, as this method has been proven to provide better performance, robustness, and an overall marginal type 1 error rate [30, 31], especially when the proportion of missing data across samples for a molecular feature is relatively low (as in our datasets, with only 11.6% of imputable variables)

composite outcome of a sustained 40% reduction in eGFR, need for renal-replacement therapy, or death from renal causes [HR 0.60

Researchers working on sensitive applications benefit from multi-stage quality verification

With any of these indications, you need to contact your medical practitioner

The copper is bound in a stable, bioavailable form