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We will propose and finalize any substantive changes ahead of the performance period so that clinicians are able to understand and provide feedback on the changes to the measure specifications prior to MIPS program implementation

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Many downstream target genes of NRF2, such as HO1, SLC7A11, FTH/L, and FPN, are related to the regulation of ferroptosis, suggesting NRF2 is a key negative regulator of ferroptosis [92]