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This only needs to be done if the vial has been stored and/or exposed to low temperatures for a period of time, not prior to every injection if the vial is properly stored at room temperature

Alzheimers Dement 2013;9:63-75

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Transgenic mice that develop thyroid-specific autoantigens in a spontaneous manner have, therefore, been very useful and provide a good platform for studying immunological mechanisms of the disease as reported by Merrill and Pandiyan (2018) (Merrill and Pandiyan 2018)