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doi: 10.3389/fimmu.2026.1779543 Received 02 January 2026 Revised 28 January 2026 Accepted 06 February 2026 Published 24 February 2026 Volume 17 - 2026 Edited by Yiju Wei, Shandong First Medical University, China Reviewed by Xingchen Peng, Sichuan University, China Lei Li, University of South China, China Updates Copyright 2026 Su, Yang and Zheng

Reduced food intake compounds the issue

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The two-layer membrane divides mitochondria into multiple cavities, which is known as mitochondrial compartmentalized structure. The mitochondrial structure mainly includes four distinct regions, including mitochondrial outer membrane (Outer Mitochondrial MembraneOMM), mitochondrial inner membrane (Inner Mitochondrial MembraneIMM), mitochondrial matrix, and intermembrane space (Kramer and Bressan, 2018)

However, the reality is far more complicated