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Here, we demonstrate that gut-selective and systemic inhibition of DPP-4 activity reduces postprandial TG excursion in young mice

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The formulation exhibited favorable physicochemical properties, including an encapsulation efficiency of 56 2%, particle size of 144 3 nm, highly negative zeta potential ( 38.6 1.4 mV), good colloidal stability under refrigerated conditions for three months, and a biphasic release profile

A 2025 review in Endocrinology found that endogenous sex hormones estrogen in particular modulate GLP-1 receptor expression in the hypothalamus, and that women experience both greater weight loss and higher rates of side effects than men on GLP-1 agonists

These could be signs of kidney dysfunction, and early treatment is important