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These alterations in cell function are due to the needs of each immunological subset for specific metabolites, signaling intermediates, or epigenetic modifications mediated by metabolite levels

Furthermore, chronic stress impairs inhibitory neurotransmitter systems

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HSP-70, a chaperone protein within the heat shock protein family, is produced by macrophages, smooth muscle cells, endometrial cells, dendritic cells, and vascular endothelial cells