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In hippocampal neuron cultures, Dihexa was reported to induce spinogenesis and synaptogenesis at picomolar concentrations the basis for the widely-cited seven orders of magnitude more potent than BDNF potency figure

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Miller JR et al (1983): The role of myosin light chain kinase phosphorylation in beta-adrenergic relaxation of tracheal smooth muscle

Generally, it's recommended to take it on an empty stomach for better absorption