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Neuroendocrine and neuroimmune research together allow us to conclude that stress, understood as distress or toxic stress, through the systemic effects of cortisol and norepinephrine, is capable of altering brain activity, by means of various mechanisms, still to be fully discovered in their complexity, that seem to center on two fundamental pathways: alteration of the structure of brain areas and circuits, induction of neuroinflammation and oxidative stress

10.1016/j.ejpb.2023.08.018 101 MohaddishM.JilaniM.RehmanU.RamaiahR.HaniU.GuptaG.et al (2025)