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It is widely accepted that alcohol use and a number of pharmacological agents, for example isoniazid, induce expression of CYP2E1 (see section Potential drug interactions with paracetamol metabolism and section Alcohol use)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Shi KQ, Tang JZ, Zhu XL, et al

However, it is unclear exactly which isoform acts in cardiomyocytes and how it exerts its anti-ferroptosis effect, which requires further study