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Physiol Rev 100(3):12911346 Rodrigues CM, Sol S, Silva RF, Brites D (2002) Aging confers different sensitivity to the neurotoxic properties of unconjugated bilirubin

Functional assays validate metabolic activity at Day 30, demonstrating comparable performance to widely used models such as primary human hepatocytes (PHHs) and HepaRG cells

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Targeting these receptors with selective agonists, partial agonists, and positive modulators has demonstrated potential in regulating neurotransmitter release and cognitive functioning, which may offer therapeutic benefits for ASD [45, 46]