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New England Journal of Medicine , Sept

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This mechanism operates primarily through the stimulation of insulin release in response to elevated blood sugar levels while simultaneously suppressing glucagon release, which contributes to glucose production in the liver

As a nuclear transcription factor, PPAR could mediate the effect of GLP-1 in alleviating hepatic steatosis by differentially regulating the expression of its target genes, including acetyl CoA carboxylase and carnitine palmitoyl transferase la both in vitro and in vivo