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By enhancing GABA signaling (which is calming) and reducing excessive glutamate activity (which drives excitation), semaglutide may lower the neurobiological 'drive' to seek out alcohol as a reward or coping mechanism

Research was done at 20 centers in seven European countries

doi:10.2133/dmpk.DMPK-10-RV-094 131

GLP-1 medications like Wegovy may increase stone risk through multiple pathways: reduced fluid intake due to appetite suppression, concentrated urine from lower hydration, and potential changes in calcium and uric acid metabolism

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