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Risk factors for greater lean tissue loss likely include advanced age, rapid or large absolute weight loss, low dietary protein intake, sedentary lifestyle, and comorbid conditions such as chronic kidney disease or long-standing diabetes [15]

Quite possibly

Tirzepatide's FDA approval marks a breakthrough in obesity treatment

The study included a survey with 1,955 useable observations including 495 people who were currently taking a GLP-1, 468 who had previously taken one, 492 people who were planning to take one, and 500 people who were neither taking one nor planning to take one

Initial weight-loss approval runs 8 months