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On December 16, 2021, FDA reissued the EUA (PDF, 493 KB) for the authorized Pfizer-BioNTech COVID-19 Vaccine, including an update on expiration dating

Furthermore, ionizing radiation triggers mitochondrial damage, releasing mtROS and mtDNA that directly activate NLRP3 (Table 2)

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If a patient, after consulting with a prescriber, has a specific medical need that cannot be met with an FDA-approved medication, then patients can be prescribed patient-specific compounded medications that may include, if appropriate, two or more active ingredients that would be impractical or impossible to administer with two separate prescription orders for each medication to fit the patients unique needs