So this is so important
Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GS
However, recent successes with weight-lowering incretin-based medicines have raised expectations for pharmaceutical pipelines to transform the management of type 2 diabetes
Importantly, the transporters, which are expressed at the membrane of brain parenchymal cells, mediate the intracellular distribution of drugs within the brain, while transporters, expressed at the BBB, and BCSFB, influence elimination of the therapeutics (48, 49)
The chart below identifies the use(s) FDA reviewed for each of the bulk drug substances being discussed at this advisory committee meeting