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The effects of altered GSH homeostasis vary with cell type, subcellular localization, and metabolic state

Other systemic illnesses, such as diabetes and hyperthyroidism, or organ diseases affecting the liver and kidneys, can also contribute to deficiency by either preventing normal absorption or disrupting vitamin storage

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Moreover, caspase-8 was found to antagonize necroptosis, as evidenced by accelerated necroptosis of erythrocytes in response to caspase-8 inhibition [198]