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This tonicity is both its strength and its limitation: it dramatically simplifies the protocol (2 injections per week), but abolishes pulsatility

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Insulin Therapy Indications for exogenous insulin therapy in patients with T2D include acute illness or surgery, pregnancy, glucose toxicity and contraindications to or failure to achieve goals with oral antidiabetic medications ( Cardiovascular Outcomes In experimental models, insulin has both pro- and anti-atherogenic actions (Potenza et al., 2009), suggesting a mixed effect on CVD