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Secretin regulates the pH of the small intestine, inhibits gastric acid secretion in the stomach, stimulates bicarb production by the pancreas, stimulates bile production by the liver, stimulates cholecystokin production which makes the gallbladder contract, and increases insulin secretion which prevents blood sugar spikes

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doi: 10.1155/2016/4361702

Second-line treatments have also been designed over the past few years, including regorafenib (antiangiogenesis) (Zhu et al., 2019)