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31 Another RCT comparing metformin (500 mg twice daily) with a twice-daily capsule containing -lipoic acid, biotin, chromium polynicotinate, and zinc sulfate, showed significant ( P 6 months), higher doses (17002000 mg), and lower baseline weight were associated with higher efficacy of metformin for treatment of AN

Potential Side Effects and Safety Considerations The most common side effects are gastrointestinal including nausea, vomiting, and diarrhoea and are most pronounced during dose escalation

Animal evidence suggests this pathway also helps preserve lean mass during weight reduction, although the human data is still maturing

[DOI] [PMC free article] [PubMed] [Google Scholar] Nilsson O, Bilchik AJ, Goldenring JR, Ballantyne GH, Adrian TE, Modlin IM

2022 May;18:9:906020