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Comment: Several commenters urged CMS to adopt a minimum 24-month timeframe for QCDRs, qualified registries, and certified EHRs to fully support new MVPs, citing the need for sufficient development, testing, certification, and deployment, in addition to allowing clinicians time to engage and onboard with intermediaries

Dissociated hippocampal neurons transfected with mRFP-p-actin were stimulated for 5 days with sub-threshold concentrations of HGF and Dihexa (2.5 ng/ml + 10 ' 13 M, respectively), biologically active doses of HGF (10 ng ml), Dihexa or Nlel-AnglV (10 "12 M) or a combination of sub-threshold doses of 2.5 ng/ml HGF + 10 "12 M Dihexa or 2.5 ng/ml HGF + 10 "12 M Nlel-AnglV

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For volumes exceeding 1 mL (e.g., 1.44 mL at maintenance dose), inject slowly over several seconds