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She said a combined approach with endoscopic sleeve gastroplasty could lead to an average weight loss of about 28% to 30% of total body weight, and with bariatric surgery, it could be from 25% to 40%

Although peptide-based therapies tend to be extremely effective, they are also short-lived and often easily degrade once inside the body

They are especially relevant for women in midlife because collagen production naturally declines with age. In my experience, the people who get the most out of them are women in their late thirties and beyond who are starting to notice changes in skin texture, nail brittleness, or joint comfort, Achari adds

The latest Novo Nordisk press release shows that oral semaglutide (9mg) led to a significant reduction in cardiovascular events in the SOUL trial, as presented at ACC 2025