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From a commercial perspective, copper peptide GHK-Cu is mainly positioned as a cosmetic ingredient used in skincare formulations, including anti-aging serums, skin repair products, and scalp care formulations

With increasing age, the melatonin levels tend to decrease due to reduced secretion, which may cause difficulty in sleep regulation

Validating urine-based biomarkers (e.g., glomerular cell-derived exosomal ferroptosis regulators, and 4-HNE metabolites) or circulating signatures that correlate with IgA nephropathy disease activity, pathological severity, or response to interventions is urgently needed to guide clinical trial design and patient stratification

Acquired PE is commonly due to sexual performance anxiety 24 , erectile dysfunction (ED) 25 , and occasionally prostatitis 26 or hyperthyroidism 12

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