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By using an electrophoretic pattern to screen pathognomonic RBC shape, HbS may be identified from other hemoglobins

Functional indicators of oxidative stress included relative levels of 3-chlorotyrosine (3-CT), an established biomarker of a chronic inflammatory response, and aconitase activity, a biomarker of mitochondrial superoxide production

Consequently, SSA was selected as the optimal extraction solution due to its balanced deproteinization efficiency and superior detector response for most analytes

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