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In another work, the combination of cyclodextrin (CDs) with agar to render chemically cross-linked hydrogels with drugs by the formation of inclusion complexes or ionic bonds with polysaccharide enhanced loading ability, dually controlled delivery, release profile based on CD affinity and tunable external stimuli such as pH and ionic strength [171]

10.1177/20420188231222367 [DOI] [PMC free article] [PubMed] [Google Scholar] 20

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95% CI, 1.724.19), major macrovascular events (HR 2.88

Results: The combination therapy suggests improved outcomes compared to metformin monotherapy, yielding significant improvements in metabolic, hormonal, and reproductive function