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Conversion of the peptide to the C -terminal thioester allowed a second NCL cycle with Cys, which then underwent radical-mediated desulfurization following Danishefsky's method (Wan and Danishefsky, 29 , bearing a carbohydrate and fluorescein modification

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Antagonists of LH-RH show no biological stimulatory activity but compete with endogenous LH-RH for the LH-RH receptor sites producing a competitive blockade of LH-RH receptors 3

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