Visible changes in brightness and evenness of skin tone may take several weeks to months, depending on baseline pigmentation, dose, route of administration, and adherence to sun protection. Results are often subtle and natural-looking, and ongoing maintenance may be required to sustain benefits, especially in individuals with high sun exposure
Low back pain associated with lumbar disc herniation: role of moderately degenerative disc and annulus fibrous tears
The effect is dose-dependent but plateaus at relatively low concentrations
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