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Exposure to electrophiles releases Nrf2 from KEAP to allow translocation to the nucleus and activation of ARE-dependent genes such as NAD(P)H quinone oxidoreductase (NQO1), glutathione transferase (GST), thioredoxin reductase (TRX), gamma-glutamyl cysteine synthase, malic enzyme, and catalase [16]

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In a clinical trial involving 34 Asian participants, DEC-containing serum significantly improved skin lightness (L*: +0.98%, P = 0.003), reduced facial sallowness (b*: 5.92%, P 50% area involvement

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As with all research peptides, comprehensive long-term safety data continues to be accumulated